Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:1,000 | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Non-human primate, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Monoclonal |
Type |
Antibody |
Clone |
F.699.5 |
Immunogen |
Synthetic peptide corresponding to human PKC lambda/iota |
Conjugate |
Unconjugated |
Form |
Liquid |
Purification |
Affinity chromatography |
Storage buffer |
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
Contains |
<0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_10986838 |
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other PKC isoforms.
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; nPKC-iota; PRKC-lambda/iota; Protein kinase C iota type; protein kinase C, iota; protein kinase C, lambda
Gene Aliases: 2310021H13Rik; AI427505; aPKClambda; DXS1179E; mKIAA4165; nPKC-iota; PKCI; Pkcl; PKClambda; PRKCI; Prkcl
UniProt ID: (Human) P41743, (Mouse) Q62074, (Rat) F1M7Y5
Entrez Gene ID: (Human) 5584, (Mouse) 18759, (Rat) 84006
Molecular Function:
non-receptor serine/threonine protein kinase
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