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PKC theta Polyclonal Antibody

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PKC theta Polyclonal Antibody

Product Details

BS-4161R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human PKC ta, amino acids 351-450.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport and the organization of cytoskeletal and extracellular matrix proteins. Increasing evidence from studies using in vitro and in vivo systems points to PKC as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. PKC-mediated control of these transitions can be negative or positive, depending on the timing of PKC activation during the cell cycle and on the specific PKC isozymes involve. There have been at least 12 different PKC isoforms identified in humans to date, including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. The different PKC isoforms vary in structure, subcellular localization, tissue distribution and response to extracellular signals. PKC beta II has been shown to be expressed, in part, in cardiac muscle, intestinal epithelium, kidney and pancreas. PKC beta II has been shown to be involved in cell cycle progression and cancer proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 2.7.11.13; kinase nPKC-theta; KPCT; MGC126514; MGC141919; nPKC-theta; PKC theta; Protein kinase C theta type; RP11-563J2.1; unnamed protein product

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Gene Aliases: A130035A12Rik; AW494342; nPKC-theta; PKC-0; PKC-theta; Pkcq; PKCtheta; PRKCQ; PRKCT

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UniProt ID: (Human) Q04759, (Mouse) Q02111

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Entrez Gene ID: (Human) 5588, (Mouse) 18761, (Rat) 85420

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding zinc ion binding kinase activity transferase activity metal ion binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
regulation of cell growth immune system process regulation of transcription, DNA-templated membrane protein ectodomain proteolysis inflammatory response axon guidance positive regulation of telomere maintenance positive regulation of interleukin-17 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production intracellular signal transduction CD4-positive, alpha-beta T cell proliferation Fc-epsilon receptor signaling pathway T cell activation negative regulation of apoptotic process negative regulation of insulin receptor signaling pathway positive regulation of T cell activation positive regulation of DNA metabolic process positive regulation of NF-kappaB transcription factor activity cell chemotaxis negative regulation of T cell apoptotic process regulation of platelet aggregation positive regulation of T-helper 17 type immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of T-helper 2 cell activation protein phosphorylation regulation of G2/M transition of mitotic cell cycle phosphorylation positive regulation of T cell proliferation positive regulation of NF-kappaB import into nucleus positive regulation of interleukin-2 biosynthetic process positive regulation of protein secretion positive regulation of filopodium assembly positive regulation of stress fiber assembly response to hypoxia aging response to heat response to glucose response to organic cyclic compound regulation of vasoconstriction neuron differentiation response to insulin tissue regeneration respiratory burst
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