PA5-29834 targets Polycystin 2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29834 immunogen is recombinant protein fragment corresponding to a region within amino acids 724 and 968 of Human Polycystin 2.
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This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.
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Protein Aliases: APKD2; Autosomal dominant polycystic kidney disease type II protein; member 2; Pc-2; PC2; PKD4; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; Polycystin-2; Polycystwin; R48321; subfamily P; transient receptor potential cation channel; Transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2; TRPP2
Gene Aliases: APKD2; Pc-2; PC2; PKD2; PKD4; TRPP2
UniProt ID: (Human) Q13563
Entrez Gene ID: (Human) 5311