This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-28700 targets Pyruvate Kinase (muscle) in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-28700 immunogen is recombinant fragment corresponding to a region within amino acids 243 and 531 of Human Pyruvate Kinase.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. PKM2 has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. PKM2 has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms of PKM2 have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CTHBP; cytosolic; Cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; muscle type; OIP-3; OIP3; OPA-interacting protein 3; p58; PK, muscle type; PK3; PKM; Pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle isozyme; Pyruvate kinase PKM; TCB; THBP1; thyroid hormone-binding protein; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; tu; Tumor M2-PK
Gene Aliases: AA414905; AL024370; AL024424; CTHBP; HEL-S-30; OIP3; Pk-2; Pk-3; PK2; PK3; PKM; PKM12; PKM2; Pykm; TCB; THBP1