Immunogen sequence: NLLTERSTFTD SQLGNADMEM TLERAVSMLE ADHMLPSRIS AAATFIQHEC FQKSEARKRV NQLRGILKLL QLLKVQNEDV QRAVC
Highest antigen sequence identity to the following orthologs - mouse 78%, rat 51%.
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PKP2; Plakophilin-2
Gene Aliases: ARVD9; PKP2
UniProt ID: (Human) D3DUW9
Entrez Gene ID: (Human) 5318