Search
Invitrogen
PLA2G2A Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 6
PLA2G2A Antibody (PA5-102403) in ICC/IF
Immunofluorescent analysis of PLA2G2A in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and PLA2G2A polyclonal antibody (Product # PA5-102403) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-102403
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PLA2G2A(Accession P14555), corresponding to amino acid residues I29-C79.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PLA2G2A.
Target Information
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.1.1.4; EF; Enhancing factor; eted enzyme type IIA phospholipase A2; GIIC sPLA2; Group IIA phospholipase A2; modifier of Min1; non-pancreatic secreted type II phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid); Phospholipase A2, membrane associated; PLA2BPLA2; PLA2G2A; PLA2LPLA2S; platelet phospholipase A2; secretory group II phospholipase A2; synovial phospholipase A-2 (EC 3.1.1.4); unnamed protein product
Gene Aliases: EF; MOM1; PLA2; PLA2B; PLA2G2A; PLA2L; PLA2S; PLAS1; RASF-A; sPLA2; sPla2-IIA
UniProt ID: (Human) P14555, (Rat) P14423, (Mouse) P31482
Entrez Gene ID: (Human) 5320, (Rat) 29692, (Mouse) 18780
lipid metabolic process
phospholipid metabolic process
inflammatory response
positive regulation of macrophage derived foam cell differentiation
lipid catabolic process
killing of cells of other organism
low-density lipoprotein particle remodeling
intestinal stem cell homeostasis
angiotensin-activated signaling pathway
negative regulation of T cell proliferation
defense response to bacterium
phosphatidylethanolamine metabolic process
phosphatidylcholine metabolic process
phosphatidylglycerol metabolic process
phosphatidic acid metabolic process
arachidonic acid secretion
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of ERK1 and ERK2 cascade
regulation of neutrophil activation
negative regulation of cell proliferation
somatic stem cell population maintenance
regulation of cell proliferation
regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
regulation of growth
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support