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Invitrogen
PLA2G2A Polyclonal Antibody
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Product Details
PA5-47729
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Sf 21-derived recombinant human PLA2G2A Asn21-Cys144
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blots, approximately 60% cross-reactivity with recombinant mouse PLA2G2A is observed and less than 5% cross-reactivity with recombinant human (rh) PLA2G1B and rhPLA2G7 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.1.1.4; GIIC sPLA2; Group IIA phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid); Phospholipase A2, membrane associated; PLA2BPLA2; PLA2G2A; PLA2LPLA2S; synovial phospholipase A-2 (EC 3.1.1.4); unnamed protein product
Gene Aliases: MOM1; PLA2; PLA2B; PLA2G2A; PLA2L; PLA2S; PLAS1; RASF-A; sPLA2
UniProt ID: (Human) P14555
Entrez Gene ID: (Human) 5320
lipid metabolic process
phospholipid metabolic process
inflammatory response
positive regulation of macrophage derived foam cell differentiation
lipid catabolic process
killing of cells of other organism
low-density lipoprotein particle remodeling
intestinal stem cell homeostasis
angiotensin-activated signaling pathway
negative regulation of T cell proliferation
defense response to bacterium
phosphatidylethanolamine metabolic process
phosphatidylcholine metabolic process
phosphatidylglycerol metabolic process
phosphatidic acid metabolic process
arachidonic acid secretion
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of ERK1 and ERK2 cascade
regulation of neutrophil activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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