Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Sequence of this protein is as follows: MADGAKANPK GFKKKVLDRC FSGWRGPRFG ASCPSRTSRS SLGMKKFFTV AILAGSVLST AHGSLLNLKA MVEAVTGRSA ILSFVGYGCY CGLGGRGQPK DEVDWCCHAH DCCYQELFDQ GCHPYVDHYD HTIENNTEIV CSDLNKTECD KQTCMCDKNM VLCLMNQTYR EEYRGFLNVY CQGPTPNCSI YEPPPEEVTC SHQSPAPPAP P
May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases. Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443). Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GIIF sPLA2; Group IIF secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 2F; phospholipase A2, group IIF; sPLA2-IIF
Gene Aliases: PLA2G2F
UniProt ID: (Human) Q9BZM2
Entrez Gene ID: (Human) 64600
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support