This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: calcium-dependent phospholipid-binding protein; cPLA2; cytosolic group IVA; Cytosolic phospholipase A2; group IVA; Lysophospholipase; MGC126350; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; phospholipase A2 cytosolic; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene Aliases: CPLA2; cPLA2-alpha; cPLA2alpha; Pla2c; PLA2G4; PLA2G4A
Molecular Function: phospholipase