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Invitrogen
PLA2G5 Polyclonal Antibody
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Product Details
PA5-42005
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human PLA2G5
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: YRFAWGVVTC EPGPFCHVNL CACDRKLVYC LKRNLRSYNP QYQYFPNILC
Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 85%; Human: 100%; Rat: 86%
Target Information
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca2+-dependent phospholipase A2; calcium-dependent phospholipase A2; DKFZp686C2294; MGC46205; Phosphatidylcholine 2-acylhydrolase 5; Phospholipase A2 group V; PLA2-10; unnamed protein product
Gene Aliases: FRFB; GV-PLA2; hVPLA(2); PLA2-10; PLA2G5
UniProt ID: (Human) P39877
Entrez Gene ID: (Human) 5322
lipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
phagocytosis
phospholipid catabolic process
positive regulation of phospholipase activity
positive regulation of macrophage derived foam cell differentiation
lipid catabolic process
leukotriene biosynthetic process
low-density lipoprotein particle remodeling
phosphatidylcholine catabolic process
negative regulation of T cell proliferation
phosphatidylcholine metabolic process
phosphatidylglycerol metabolic process
arachidonic acid secretion
positive regulation of phagocytosis
positive regulation of ERK1 and ERK2 cascade
positive regulation of immune complex clearance by monocytes and macrophages
phagosome-lysosome fusion
positive regulation of opsonization
positive regulation of antifungal innate immune response
positive regulation of phagosome maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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