Invitrogen

PLA2G6 Polyclonal Antibody

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PLA2G6 Antibody in Immunofluorescence (IF) — Immunofluorescent staining of PLA2G6 in human cell line A-431 shows positivity in microtubule organizing center. Samples were probed using a PLA2G6 Polyclonal Antibody (Product # PA5-51525).

PLA2G6 Antibody in Western Blot (WB) — Western blot analysis of PLA2G6 in control (vector only transfected HEK293T lysate) and PLA2G6 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a PLA2G6 Polyclonal Antibody (Product # PA5-51525).

Product Details

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC)

0.25-2 µg/mL

Immunofluorescence (IF)

0.25-2 µg/mL

Western Blot (WB)

0.04-0.4 µg/mL

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PLA2G6

Conjugate

Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2645616

Product Specific Information

Immunogen sequence: QVLHTEVLQH LTDLIRNHPS WSVAHLAVEL GIRECFHHSR IISCANCAEN EEGCTPLHLA CRKGDGEILV ELVQYCHTQM DVTDYKGETV FHYAVQGDNS QVLQLLGRNA VAGLNQVNNQ GLTPLHLACQ LGKQEMVRVL LLCNARCNIM G

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

Target Information

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; neurodegeneration with brain iron accumulation 2; Patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9

Gene Aliases: CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PLA2G6; PLPLA9; PNPLA9

UniProt ID: (Human) O60733

Entrez Gene ID: (Human) 8398

Molecular Function: enzyme modulator hydrolase lipase phospholipase