Phospholipase A-2-activating protein (PLAA), also named PLAP, can interact with ubiquitin and is involved in the maintenance of ubiquitin levels. PLAA contains multiple consensus domains including WD repeats, PFU domain and PUL domain. Although the function of PLAA remains unclear, ubiquitin binding of PLAA might be the central role that connects ubiquitination and degradation in ERAD. Recent finding revealed that PLAA served as a novel nociceptive mediator after incision, and its expression level is regulated by miR-203.
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Protein Aliases: DOA1; DOA1 homolog; Phospholipase A-2-activating protein; phospholipase A2-activating protein; PLA2P; PLAA; PLAP
Gene Aliases: DOA1; PLA2P; PLAA; PLAP
UniProt ID: (Human) Q9Y263
Entrez Gene ID: (Human) 9373
Molecular Function: enzyme modulator