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Product Details
PA5-65970
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PLAGL1. Recombinant protein control fragment (Product #RP-105023).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2665151
Product Specific Information
Immunogen sequence: QELMKESLQTG DLLSTFHTIS PSFQLKAAAL PPFPLGASAQ NGLASSLPAE VHSLTLSPPE QAAQPMQPLP ESLASLHPSV SPGSP
Highest antigen sequence identity to the following orthologs - mouse 50%, rat 47%.
Target Information
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lost on transformation 1; LOT-1; PLAG-like 1; pleiomorphic adenoma gene-like 1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC; Zinc finger protein PLAGL1
Gene Aliases: LOT1; PLAGL1; ZAC; ZAC1
UniProt ID: (Human) Q9UM63
Entrez Gene ID: (Human) 5325
transcription from RNA polymerase II promoter
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
cell differentiation
skeletal muscle cell differentiation
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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