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Invitrogen
PLAGL2 Polyclonal Antibody
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Product Details
PA5-100303
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PLAGL2(Accession Q9UPG8), corresponding to amino acid residues R28-A78.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PLAGL2.
Target Information
The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C2H2-type zinc finger protein; KIAA0198; pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; pleomorphic adenoma gene like 2; unnamed protein product; Zinc finger protein PLAGL2
Gene Aliases: AU018672; AW552839; KIAA0198; mKIAA0198; PLAGL2; ZNF900
UniProt ID: (Human) A8K8T5
Entrez Gene ID: (Human) 5326, (Mouse) 54711, (Rat) 296281
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
C2H2 zinc finger transcription factor
regulation of transcription from RNA polymerase II promoter
lipid metabolic process
post-embryonic development
chylomicron assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of intrinsic apoptotic signaling pathway
transcription from RNA polymerase II promoter
positive regulation of protein targeting to mitochondrion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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