PA5-29277 targets PLCG2 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29277 immunogen is recombinant fragment corresponding to a region within amino acids 70 and 360 of Human PLCG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.
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Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; 5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2 (phosphatidylinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC-gamma-2; PLC-IV
Gene Aliases: APLAID; FCAS3; PLC-gamma-2; PLC-IV; Plcg-2; PLCG2; PLCgamma2