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Invitrogen
PLD6 Polyclonal Antibody
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Product Details
PA5-46348
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human PLD6 (aa 188-237).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: ITEDDEYVRL FLEEFERIWE QFNPTKYTFF PPKKSHGSCA PPVSRAGGRL
Sequence homology: Human: 100%
Target Information
PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Choline phosphatase 6; Mitochondrial cardiolipin hydrolase; Mitochondrial phospholipase; MitoPLD; Phosphatidylcholine-hydrolyzing phospholipase D6; Phospholipase D6; PLD 6; PLD6; Protein zucchini homolog; unnamed protein product; Zucchini endoribonuclease
Gene Aliases: PLD6; ZUC
UniProt ID: (Human) Q8N2A8
Entrez Gene ID: (Human) 201164
catalytic activity
nuclease activity
endonuclease activity
phospholipase activity
protein binding
phosphoric diester hydrolase activity
zinc ion binding
hydrolase activity
endoribonuclease activity, producing 5'-phosphomonoesters
cardiolipin hydrolase activity
identical protein binding
protein homodimerization activity
metal ion binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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