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Invitrogen
PLD6 Polyclonal Antibody
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FIGURE: 1 / 4
PLD6 Antibody (PA5-71510) in WB
Western blot analysis of PLD6 in human ovary and mouse testis tissue lysates (from left to right). Samples were incubated with PLD6 polyclonal antibody (Product # PA5-71510) using a dilution of 1:1,000 followed by goat anti-rabbit IgG H&L (HRP) at a dilution of 1:5,000. Lysates at 35 µg per lane.
Product Details
PA5-71510
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 125-154 amino acids from of human PLD6
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Choline phosphatase 6; Mitochondrial cardiolipin hydrolase; Mitochondrial phospholipase; MitoPLD; mZuc; novel Phospholipase D Active site motif-containing protein; Phosphatidylcholine-hydrolyzing phospholipase D6; Phospholipase D6; PLD 6; PLD6; Protein zucchini homolog; unnamed protein product; Zucchini endoribonuclease
Gene Aliases: 4933433K01Rik; Gm10; mitoPLD; mZuc; PLD6; ZUC
UniProt ID: (Human) Q8N2A8, (Mouse) Q5SWZ9
Entrez Gene ID: (Human) 201164, (Mouse) 194908
catalytic activity
nuclease activity
endonuclease activity
phospholipase activity
protein binding
phosphoric diester hydrolase activity
zinc ion binding
hydrolase activity
endoribonuclease activity, producing 5'-phosphomonoesters
cardiolipin hydrolase activity
identical protein binding
protein homodimerization activity
metal ion binding
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
phospholipase
lipid metabolic process
spermatogenesis
spermatid development
mitochondrial fusion
phospholipid biosynthetic process
positive regulation of mitochondrial fusion
lipid catabolic process
cell differentiation
P granule organization
piRNA metabolic process
meiotic cell cycle
meiotic nuclear division
DNA methylation involved in gamete generation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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