Peptide sequence: DLTIPKHRHL LQAKNQEEKR LWIHCLQRLF FENHPASIPA KAKQVLLENS
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 100%
PLEKHG2 may be a transforming oncogene with exchange activity for CDC42. PLEKHG2 may be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42.PLEKHG2 activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).
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Protein Aliases: ARHGEF42; CLG; Common site lymphoma/leukemia GEF; Common site lymphoma/leukemia guanine nucleotide exchange factor; common-site lymphoma/leukemia GEF; common-site lymphoma/leukemia guanine nucleotide exchange factor; CTB-60E11.4; DKFZp667J2325; family G (with RhoGef domain) member 2; FLJ00018; FLJ22458; FLJ38638; PH domain-containing family G member 2; Pleckstrin homology domain containing; pleckstrin homology domain containing, family G (with RhoGef domain) member 2; Pleckstrin homology domain-containing family G member 2
Gene Aliases: AI194308; ARHGEF42; CLG; Cslg; LDAMD; PLEKHG2; RGD1310112