Immunogen sequence: ATRRELFSGS NPGKLGEPPS GGKAGPEEDE EGVSFTDFQP QDVTQHQGFP DELAFRSCSE IRSAWQALEQ GQLARPGFPE PLLILEDSDL GGDSGSGKAG APSSERTASR VRELARLYSE RI
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 77%.
PLEKHG2 may be a transforming oncogene with exchange activity for CDC42. PLEKHG2 may be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42.PLEKHG2 activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).
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Protein Aliases: ARHGEF42; CLG; common-site lymphoma/leukemia guanine nucleotide exchange factor; CTB-60E11.4; DKFZp667J2325; family G (with RhoGef domain) member 2; FLJ00018; FLJ22458; FLJ38638; PH domain-containing family G member 2; Pleckstrin homology domain containing; pleckstrin homology domain containing, family G (with RhoGef domain) member 2; Pleckstrin homology domain-containing family G member 2
Gene Aliases: ARHGEF42; CLG; LDAMD; PLEKHG2
UniProt ID: (Human) Q9H7P9
Entrez Gene ID: (Human) 64857