Immunogen sequence: PATTPLPEHK SHMVIPAPST AFCPEQGHCA DIHVPTTPAL PKEICSDFTV SVTTPVPKQE GHLDSESPTN IPLTKQGGSR DVQGPDPVCS QPIQPLSWHG SSLDPQGPGD TLPPLPCHLP D
Highest antigen sequence identity to the following orthologs: Mouse - 35%, Rat - 34%.
PLEKHG2 may be a transforming oncogene with exchange activity for CDC42. PLEKHG2 may be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42.PLEKHG2 activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARHGEF42; CLG; common-site lymphoma/leukemia guanine nucleotide exchange factor; CTB-60E11.4; DKFZp667J2325; family G (with RhoGef domain) member 2; FLJ00018; FLJ22458; FLJ38638; PH domain-containing family G member 2; Pleckstrin homology domain containing; pleckstrin homology domain containing, family G (with RhoGef domain) member 2; Pleckstrin homology domain-containing family G member 2
Gene Aliases: ARHGEF42; CLG; LDAMD; PLEKHG2
UniProt ID: (Human) Q9H7P9
Entrez Gene ID: (Human) 64857