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Invitrogen
PLEKHG5 Polyclonal Antibody
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Product Details
PA5-100304
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PLEKHG5(Accession O94827), corresponding to amino acid residues S844-E894.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PLEKHG5.
Target Information
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GEF720; Guanine nucleotide exchange factor 720; Neuronal RhoA GEF protein; NFkB activating protein; novel PH domain-containing protein; PH domain-containing family G member 5; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; Pleckstrin homology domain-containing family G member 5; RhoA-specific guanine exchange factor SYX1; RhoA-specific guanine exchange factor SYX2; synectin-binding guanine exchange factor; Synectin-binding RhoA exchange factor; SYX; Transcript highly enriched in cortex and hippocampus; unnamed protein product
Gene Aliases: ARHGEF45; BC023181; CMTRIC; DSMA4; GEF720; HMNR4; KIAA0720; PLEKHG5; Syx; Tech
UniProt ID: (Human) O94827, (Rat) Q6RFZ7, (Mouse) Q66T02
Entrez Gene ID: (Human) 57449, (Rat) 310999, (Mouse) 269608
Rho protein signal transduction
endothelial cell chemotaxis
positive regulation of I-kappaB kinase/NF-kappaB signaling
endothelial cell migration
regulation of small GTPase mediated signal transduction
signal transduction
regulation of Rho protein signal transduction
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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