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Proteintech
PLEKHM1 Polyclonal Antibody
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Product Details
16202-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PLEKHM1 Fusion Protein Ag9145 (708-1056 aa encoded by BC064361)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EALKCFRIR NNEKMLSDSH GVETIRDILP DTSLGGPSFF KIITAKAVLK LQAGNAEEAA LWRDLVRKVL ASYLETAEEA VTLGGSLDEN CQEVLKFATR ENGFLLQYLV AIPMEKGLDS QGCFCAGCSR QIGFSFVRPK LCAFSGLYYC DICHQDDASV IPARIIHNWD LTKRPICRQA LKFLTQIRAQ PLINLQMVNA SLYEHVERMH LIGRRREQLK LLGDYLGLCR SGALKELSKR LNHRNYLLES PHRFSVADLQ QIADGVYEGF LKALIEFASQ HVYHCDLCTQ RGFICQICQH HDIIFPFEFD TTVRCAECKT VFHQSCQAVV KKGCPRCARR RKYQEQNIFA (708-1056 aa encoded by BC064361)
Target Information
PLEKHM1 is a member of the M family of Pleckstrin homolog domain-containing proteins, a group of proteins containing a RUN domain, two pleckstrin homology domains, and a cysteine-rich domain. It was identified through segregation analysis as a cause of osteopetrosis in humans. PLEKHM1 co-localizes with Rab7 to late endosomal/lysosomal vesicles in HEK293 and osteoclast-like cells, with this co-localization dependent on the prenylation of Rab7. Monocytes from a patient homozygous for a mutated form of PLEKHM1differentiated into osteoclasts normally, but failed to form ruffled borders and showed little evidence of bone resorption when cultured on dentine discs. Another mutation of PLEKHM1 impaired vesicular acidification and increased TRACP secretion in osteoclasts, suggesting that PLEKHM1 has critical roles in endosomal maturation and may be important in osteoclast-osteoblast cross-talk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 162 kDa adapter protein; AP162; PH domain-containing family M member 1; pleckstrin homology domain containing, family M (with RUN domain) member 1; Pleckstrin homology domain-containing family M member 1; unnamed protein product
Gene Aliases: AP162; B2; BC038943; D330036J23Rik; KIAA0356; OPTA3; OPTB6; PLEKHM1
UniProt ID: (Human) Q9Y4G2, (Mouse) Q7TSI1, (Rat) Q5PQS0
Entrez Gene ID: (Human) 9842, (Mouse) 353047, (Rat) 303584
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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