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Proteintech
PLEKHO1 Polyclonal Antibody
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Product Details
24883-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PLEKHO1 Fusion Protein Ag19309 (175-409 aa encoded by BC010149)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VASTSTSDG MLTLDLIQEE DPSPEEPTSC AESFRVDLDK SVAQLAGSRR RADSDRIQPS ADRASSLSRP WEKTDKGATY TPQAPKKLTP TEKGRCASLE EILSQRDAAS ARTLQLRAEE PPTPALPNPG QLSRIQDLVA RKLEETQELL AEVQGLGDGK RKAKDPPRSP PDSESEQLLL ETERLLGEAS SNWSQAKRVL QEVRELRDLY RQMDLQTPDS HLRQTTPHSQ YRKSLM (175-409 aa encoded by BC010149)
Target Information
CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting protein 1; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; CKIP-1; pleckstrin-homology domain containing protein; HQ0024c protein; JBP; Jun zipper-associated 2; Osteoclast maturation-associated gene 120 protein; PH domain-containing family O member 1; Pleckstrin homology domain-containing family O member 1; RP11-458I7.3; similar to mouse c-Jun leucine zipper interactive; TNF intracellular domain-interacting protein; unnamed protein product
Gene Aliases: 2810052M02Rik; CKIP-1; CKIP1; HQ0024c; JBP; JZA-20; Jza2; OC120; PLEKHO1
UniProt ID: (Human) Q53GL0, (Mouse) Q9JIY0
Entrez Gene ID: (Human) 51177, (Mouse) 67220
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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