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Invitrogen

PLK1 Polyclonal Antibody

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PLK1 Polyclonal Antibody

Product Details

PA1-41319

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A portion of amino acids 100-200 of human PLK1.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2167600

Product Specific Information

Suggested positive control: human HCT-116 or mouse NIH-3T3 cell line.

Immunogen sequence homology: Xenopus (87%).

Target Information

PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cell cycle regulated protein kinase; PLK 1; PLK-1; polo (Drosophia)-like kinase; polo-like kinase; Polo-like kinase 1; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; unnamed protein product

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Gene Aliases: PLK; PLK1; STPK13

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UniProt ID: (Human) P53350

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Entrez Gene ID: (Human) 5347

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Function(s)
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding microtubule binding anaphase-promoting complex binding kinase activity transferase activity protein kinase binding identical protein binding protein serine kinase activity
Process(es)
mitotic sister chromatid segregation G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation mitotic cell cycle nuclear division mitotic cytokinesis double-strand break repair via homologous recombination microtubule bundle formation double-strand break repair protein phosphorylation mitotic spindle organization sister chromatid cohesion mitotic chromosome condensation mitotic nuclear envelope disassembly metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint mitotic G2 DNA damage checkpoint centrosome cycle regulation of mitotic cell cycle regulation of cell cycle process female meiosis chromosome segregation protein ubiquitination peptidyl-serine phosphorylation regulation of mitotic metaphase/anaphase transition protein destabilization positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis protein localization to organelle negative regulation of apoptotic process homologous chromosome segregation establishment of protein localization positive regulation of proteolysis Golgi inheritance nuclear envelope disassembly centrosome separation cell division positive regulation of ubiquitin-protein transferase activity regulation of cell cycle synaptonemal complex disassembly protein localization to chromatin protein localization to centrosome protein localization to nuclear envelope double-strand break repair via alternative nonhomologous end joining positive regulation of protein localization to nucleus regulation of mitotic spindle assembly regulation of mitotic cell cycle phase transition positive regulation of ubiquitin protein ligase activity regulation of protein localization to cell cortex regulation of anaphase-promoting complex-dependent catabolic process protein localization to site of double-strand break negative regulation of double-strand break repair via homologous recombination
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