This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: DHTKLILSGW EPLLVTFVAR NRSACTYLAS HLRQLGCSPD LRQRLRYALR LL
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
CNK, a member of the CDC5/Polo subfamily of Ser/Thr protein kinases, is involved in regulating M phase functions during the cell cycle. It may also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein. This membrane-associated protein binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain. Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. This protein exhibits a short half-live. In cells of hematopoietic origin, CNK is strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. Cytokine and cellular adhesion trigger CNK induction. CNK is thought to be phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis The protein contains 2 POLO box domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cnk; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Fnk; PLK-3; Plk3; Polo-like kinase 3; Proliferation-related kinase; Serine/threonine-protein kinase PLK3
Gene Aliases: CNK; FNK; PLK-3; PLK3; PRK
UniProt ID: (Human) Q9H4B4
Entrez Gene ID: (Human) 1263