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Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX22642-PEP)..
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells. The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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