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Invitrogen
PLK5 Polyclonal Antibody
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Product Details
PA5-50128
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from internal of human PLK5.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total PLK5 protein.
Target Information
Polo-like kinase 5 (PLK5) is a member of the Polo-like kinase family, notable for its involvement in cell cycle regulation processes such as mitotic entry, spindle formation, and cytoplasmic division. PLK5 is distinguished from other family members by its low expression levels, particularly within different immunophenotypes, except for being notably elevated in the C5 subtype. Its expression has been linked to poor prognosis in non-small cell lung cancer, although this is not universally supported by all data sources, suggesting complex roles in tumor biology. In a mouse model, PLK5 functions as a DNA damage-inducible gene with nucleolar localization, facilitated by a specific nucleolus localization signal in its N-terminal. The protein's ectopic expression can lead to G1 phase arrest, indicating its role in cellular response to DNA damage. Research is ongoing to fully elucidate its function and prognostic implications across various cancer types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inactive serine/threonine-protein kinase PLK5; PLK-5; Polo-like kinase 5; polo-like kinase 5, pseudogene; unnamed protein product
Gene Aliases: FG060302; PLK-5; PLK5; PLK5P; SgK384ps
UniProt ID: (Human) Q496M5
Entrez Gene ID: (Human) 126520
defense response to tumor cell
cellular response to DNA damage stimulus
mitotic spindle organization
regulation of cell cycle process
positive regulation of neuron projection development
cell differentiation
regulation of apoptotic process
cell division
cellular response to growth factor stimulus
regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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