This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: PAKFSLVGIG GQDLNDGNQT LTLALVWQLM RRYTLNVLED LGDGQKANDD IIVNWVNRTL SEAGKSTSIQ SFKDKTISSS LAVVDLIDAI QPGCINYDLV KSGNLTEDDK HNNAKYAVSM ARRIGARVYA LPEDLVEVKP GAPHR
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 90%.
Phospholipid scramblases (PLS) translocate phospholipids bidirectionally between inner and outer leaflets of the plasma membrane and are implicated in apoptosis (1,2). Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Plastin-3; T fimbrin; T plastin; T-plastin
Gene Aliases: BMND18; PLS3; T-plastin
UniProt ID: (Human) P13797
Entrez Gene ID: (Human) 5358