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PLXNB1 Antibody (PA5-87560) in WB
Western blot analysis of PLXNB1 in extracts of various cell lines. Samples were incubated with PLXNB1 Polyclonal antibody (Product # PA5-87560) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-87560
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 250-470 of human PLXNB1 (NP_0026642)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804254
Product Specific Information
Immunogen sequence: RVCLRDQHYY SYVELPLACE GGRYGLIQAA AVATSREVAH GEVLFAAFSS AAPPTVGRPP SAAAGASGAS ALCAFPLDEV DRLANRTRDA CYTREGRAED GTEVAYIEYD VNSDCAQLPV DTLDAYPCGS DHTPSPMASR VPLEATPILE WPGIQLTAVA VTMEDGHTIA FLGDSQGQLH RVYLGPGSDG HPYSTQSIQQ GSAVSRDLTF DGTFEHLYVM T; Positive Samples: LO2, Mouse lung; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1gene. Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: plexin 1; plexin 5; plexin-A1; Plexin-B1; Semaphorin receptor SEP
Gene Aliases: 2900002G15Rik; AU042020; KIAA0407; mKIAA0407; PLEXIN-B1; PLXN5; PLXNB1; SEP
UniProt ID: (Human) O43157, (Mouse) Q8CJH3
Entrez Gene ID: (Human) 5364, (Mouse) 235611
negative regulation of cell adhesion
signal transduction
regulation of cell shape
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
regulation of cell migration
negative regulation of osteoblast proliferation
intracellular signal transduction
regulation of GTPase activity
positive regulation of GTPase activity
ossification involved in bone maturation
axon extension
neuron projection morphogenesis
positive regulation of axonogenesis
regulation of cytoskeleton organization
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
semaphorin-plexin signaling pathway involved in axon guidance
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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