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Invitrogen
PLXND1 Polyclonal Antibody
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FIGURE: 1 / 1
PLXND1 Antibody (PA5-143748) in WB
Western blot of PLXND1 in human endothelial cells (HUVEC) (lanes 1-6). The blots were probed with rabbit PLXND1 polyclonal antibody (Product # PA5-143749) (lanes 1 & 2), PLXND1 polyclonal antibody (Product # PA5-143748) (lanes 3 & 4), and PLXND1 polyclonal antibody (Product # PA5-143750) (lanes 5 & 6). Each antibody was used in the presence of their respective blocking peptide (lanes 2, 4 & 6).
Product Details
PA5-143748
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Plexin D1 synthetic peptide (coupled to carrier protein) corresponds to amino acids in the cytoplasmic domain from human Plexin D1. This sequence is well conserved in rat and mouse Plexin D1, and has low homology to other Plexin family members.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects 250, 215, and 195 kDa bands corresponding to the apparent molecular mass of Plexin D1 variants in human umbilical vein endothelial cells.
Target Information
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC75353; plexin family member; Plexin-D1; unnamed protein product
Gene Aliases: 6230425C21Rik; b2b1863Clo; b2b553Clo; CHTD9; KIAA0620; PLEXD1; PLXND1
UniProt ID: (Human) Q9Y4D7, (Mouse) Q3UH93
Entrez Gene ID: (Human) 23129, (Mouse) 67784, (Rat) 312652
angiogenesis
patterning of blood vessels
kidney development
outflow tract morphogenesis
cardiac septum development
negative regulation of cell adhesion
synapse assembly
synaptic target recognition
regulation of cell shape
regulation of cell migration
aorta development
negative regulation of neuron apoptotic process
endothelial cell migration
regulation of angiogenesis
positive regulation of axonogenesis
dichotomous subdivision of terminal units involved in salivary gland branching
coronary vasculature development
semaphorin-plexin signaling pathway
signal transduction
multicellular organism development
positive regulation of protein binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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