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Abnova
PMAIP1 Polyclonal Antibody, MaxPab™
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Product Details
H00005366-B03P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PMAIP1 (AAH32663, 1 a.a. approximately 136 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPGKKARKNA QPSPARAPAG PAGTAGTARD QAGFAIGMQL RFTRGKKLLS SSLSSSPLAL PRGHEEQVQV AGSRVCYSTQ EIWRQTELPA ETSESDIQTL LLRNLTASKT CMRGLLQKSF LRRCTFHQFE ERLHCN
Target Information
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adult T cell leukemia-derived PMA-responsive; Immediate-early-response protein APR; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Protein Noxa
Gene Aliases: APR; NOXA; PMAIP1
UniProt ID: (Human) Q13794
Entrez Gene ID: (Human) 5366
release of cytochrome c from mitochondria
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to UV
response to X-ray
proteasomal protein catabolic process
positive regulation of glucose metabolic process
negative regulation of mitochondrial membrane potential
positive regulation of protein oligomerization
cellular response to glucose starvation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
T cell homeostasis
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to dsRNA
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of neuron apoptotic process
regulation of mitochondrial membrane permeability
negative regulation of fibroblast proliferation
defense response to virus
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to hypoxia
intrinsic apoptotic signaling pathway by p53 class mediator
reactive oxygen species metabolic process
positive regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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