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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PMCA2 ATPase Antibodies

          Proteintech

          PMCA2 Polyclonal Antibody

          4 References
          View all (6) PMCA2 ATPase antibodies
          Datasheet
          Protocols
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          Datasheet
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          Questions & Answers

          Cite PMCA2 Polyclonal Antibody

          • Antibody Testing Data (4)
          PMCA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          PMCA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          PMCA2 Antibody (19678-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded human brain using 19678-1-AP (PMCA2 antibody) at dilution of 1:100 (under 40x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          PMCA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PMCA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PMCA2 Antibody in Western Blot (WB)
          PMCA2 Antibody in Western Blot (WB)

          Product Details

          19678-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:4,000
          View 4 publications 4 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -
          Product Specifications

          Species Reactivity

          Human

          Published species

          Fish

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Peptide

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.19 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Target Information

          The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: ATPase, Ca++ transporting, plasma membrane 2; plasma membrane Ca(2+)-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; Plasma membrane calcium-transporting ATPase 2; PMCA2

          View more View less

          Gene Aliases: ATP2B2; PMCA2; PMCA2a; PMCA2i

          View more View less

          UniProt ID: (Human) Q01814

          View more View less

          Entrez Gene ID: (Human) 491

          View more View less

          Function(s)
          calcium-transporting ATPase activity protein binding calmodulin binding ATP binding calcium-dependent ATPase activity metal ion binding primary active transporter
          Process(es)
          transport calcium ion transport organelle organization lactation sensory perception of sound locomotory behavior regulation of cell size cerebellar Purkinje cell differentiation cerebellar granule cell differentiation neuron differentiation ion transmembrane transport locomotion serotonin metabolic process otolith mineralization cGMP metabolic process regulation of synaptic plasticity synapse organization neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport auditory receptor cell stereocilium organization calcium ion transmembrane transport cochlea development regulation of cardiac conduction
          It has to be done as per old AB suggested Products section.
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