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Product Details
28423-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PMCA2 fusion protein Ag28994
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LDLKQDYEPV RSQMPEEKLY KVYTFNSVRK SMSTVIKLPD ESFRMYSKGA SEIVLKKCCK ILNGAGEPRV FRPRDRDEMV KKVIEPMACD GLRTICVAYR DFPSSPEPDW DNENDILNEL TCICVVGIED PVRPEVPEAI RKCQRAGITV RMVTGDNINT ARAIAIKCGI IHPGEDFLCL EGKEFNRRIR NEKGEIEQER IDKIW
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase, Ca++ transporting, plasma membrane 2; deaf waddler; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; Plasma membrane calcium-transporting ATPase 2; PMCA2; wriggle
Gene Aliases: ATP2B2; D6Abb2e; dfw; Gena300; jog; PMCA2; PMCA2a; PMCA2i; Tmy; wms; wri
UniProt ID: (Human) Q01814, (Rat) P11506, (Mouse) Q9R0K7
Entrez Gene ID: (Human) 491, (Rat) 24215, (Mouse) 11941
calcium-transporting ATPase activity
protein binding
calmodulin binding
ATP binding
calcium-dependent ATPase activity
metal ion binding
calcium ion binding
protein C-terminus binding
PDZ domain binding
acetylcholine receptor binding
glutamate receptor binding
nucleotide binding
hydrolase activity
primary active transporter
transport
calcium ion transport
organelle organization
lactation
sensory perception of sound
locomotory behavior
regulation of cell size
cerebellar Purkinje cell differentiation
cerebellar granule cell differentiation
neuron differentiation
ion transmembrane transport
locomotion
serotonin metabolic process
otolith mineralization
cGMP metabolic process
regulation of synaptic plasticity
synapse organization
neuromuscular process controlling balance
detection of mechanical stimulus involved in sensory perception of sound
regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
auditory receptor cell stereocilium organization
calcium ion transmembrane transport
cochlea development
regulation of cardiac conduction
cell morphogenesis
neural retina development
cellular calcium ion homeostasis
brain development
metabolic process
cerebellum development
cerebellar Purkinje cell layer morphogenesis
inner ear morphogenesis
inner ear development
inner ear receptor cell differentiation
calcium ion export
ion transport
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