Search
Bioss
PMCA2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
BS-6499R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PMCA, amino acids 361-460.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase, Ca++ transporting, plasma membrane 2; deaf waddler; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; plasma membrane calcium-ATPase isoform 2 alternative splice variant a at splice site C; plasma membrane calcium-ATPase isoform 2, splice variant i; Plasma membrane calcium-transporting ATPase 2; PMCA2; wriggle
Gene Aliases: ATP2B2; D6Abb2e; DFNA82; dfw; Gena300; jog; PMCA2; PMCA2a; PMCA2i; Tmy; wms; wri
UniProt ID: (Human) Q01814, (Rat) P11506, (Mouse) Q9R0K7
Entrez Gene ID: (Human) 491, (Rat) 24215, (Mouse) 11941
nucleotide binding
calcium-transporting ATPase activity
calcium ion binding
protein binding
calmodulin binding
ATP binding
ATPase activity
PDZ domain binding
metal ion binding
P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
protein C-terminus binding
calcium-dependent ATPase activity
acetylcholine receptor binding
glutamate receptor binding
hydrolase activity
primary active transporter
ion transport
calcium ion transport
sensory perception of sound
neuron differentiation
ion transmembrane transport
regulation of cytosolic calcium ion concentration
calcium ion transmembrane transport
regulation of postsynaptic cytosolic calcium ion concentration
regulation of cardiac conduction
cell morphogenesis
neural retina development
cellular calcium ion homeostasis
organelle organization
brain development
lactation
locomotory behavior
metabolic process
regulation of cell size
cerebellum development
cerebellar Purkinje cell layer morphogenesis
cerebellar Purkinje cell differentiation
cerebellar granule cell differentiation
locomotion
serotonin metabolic process
inner ear morphogenesis
otolith mineralization
cGMP metabolic process
regulation of synaptic plasticity
inner ear development
synapse organization
neuromuscular process controlling balance
detection of mechanical stimulus involved in sensory perception of sound
positive regulation of calcium ion transport
auditory receptor cell stereocilium organization
inner ear receptor cell differentiation
cochlea development
calcium ion export
transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support