This antibody is predicted to react with mouse and rat based on sequence homology.
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
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Protein Aliases: 95 kDa melanocyte-specific secreted glycoprotein; D12S53E; gp100; M-alpha; M-beta; ME20; ME20-M; ME20-S; ME20M; Melanocyte protein mel 17; Melanocyte protein PMEL; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; P1; P100; P26; Pmel 17; PMEL17; Premelanosome protein; Secreted melanoma-associated ME20 antigen; SI; SIL; SILV; silver (mouse homolog) like; silver (mouse homolog)-like; silver homolog; silver homolog (mouse); Silver locus protein homolog; Silver, mouse, homolog of
Gene Aliases: D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL; PMEL17; SI; SIL; SILV
UniProt ID: (Human) P40967
Entrez Gene ID: (Human) 6490