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Positive test controls include: Rat spleen, Rat lung, Rat kidney. The target is usually found in the following locations: Cytoplasm, Cytoplasmic side, Early endosome membrane, Endoplasmic reticulum membrane, Nucleus, PML body, Peripheral membrane protein, nucleolus, nucleoplasm.
Immunogen sequence: AVDARYQRDY EEMASRLGRL DAVLQRIRTG SALVQRMKCY ASDQEVLDMH GFLRQALCRL RQEEPQSLQA AVRTDGFDEF KVRLQDLSSC ITQGKDAAVS KKASPEAAST PRDPIDVDLP EEAERVKAQV QALGLAEAQP MAVVQSVPGA HPVPVYAFSI KGPSYGEDVS NTTTAQKRKC SQTQCPRKVI KMESEEGKEA RLARSSPEQP RPSTSKAVSP PHLDGPPSPR SPVIGSEVFL PNSNHVASGA GEAEERVVVI SSSEDSDAEN SSSRELDDSS SESSDLQLEG PSTLRVLDEN L
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. [Uniprot]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 SUMO-protein ligase PML; PML/RARA fusion; probable transcription factor PML; promyelocytic leukemia; Promyelocytic leukemia protein; promyelocytic leukemia, inducer of; Protein PML; RING finger protein 71; RING-type E3 SUMO transferase PML; TRIM19; tripartite motif protein TRIM19; Tripartite motif-containing protein 19
Gene Aliases: 1200009E24Rik; AI661194; MYL; PML; PP8675; RGD1562602; RNF71; TRIM19
UniProt ID: (Human) P29590, (Mouse) Q60953
Entrez Gene ID: (Human) 5371, (Mouse) 18854, (Rat) 315713
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