The synthetic peptide sequence is 140-177aa, LADFWCFECEQLICSKCFEAHQWYLKHEARPLADLRDN
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: Pml; probable transcription factor PML; Protein PML
Gene Aliases: 1200009E24Rik; AI661194; Pml; Trim19
UniProt ID: (Mouse) Q60953
Entrez Gene ID: (Mouse) 18854