Immunogen sequence: AVDARYQRDY EEMASRLGRL DAVLQRIRTG SALVQRMKCY ASDQEVLDMH GFLRQALCRL RQEEPQSLQA AVRTDGFDEF KVRLQDLSSC ITQGKDAAVS KKASPEAAST PRDPIDVDLD VSNTTTAQKR KCSQTQCPRK VIKMESEEGK EARLARSSPE QPRPSTSKAV SPPHLDGPPS PRSPVIGSEV FLPNSNHVAS GAGEAEERVV VISSSEDSDA ENSCMEPMET AEPQSSPAHS SPAHSSPAHS SPVQSLLRAQ GASSLPCGTY HPPAWPPHQP AEQAATPDAE PHSEPPDHQE R; Positive Samples: DU145; Cellular Location: Cytoplasm, Cytoplasmic side, Early endosome membrane, Endoplasmic reticulum membrane, Nucleus, PML body, Peripheral membrane protein, nucleolus, nucleoplasm
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the proteiNULLs central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: PML/RARA fusion; probable transcription factor PML; promyelocytic leukemia; Promyelocytic leukemia protein; promyelocytic leukemia, inducer of; Protein PML; RING finger protein 71; tripartite motif protein TRIM19; Tripartite motif-containing protein 19
Gene Aliases: 1200009E24Rik; AI661194; MYL; PML; PP8675; RGD1562602; RNF71; TRIM19