PMM1, also named as PMMH22, belongs to the eukaryotic PMM family. It catalyzes the second step in the conversion of fructose-6P to GDP-mannose is and is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, PMM1 may be responsible for the degradation of glucose-1, 6-bisphosphate in ischemic brain.
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Protein Aliases: brain glucose-1,6-bisphosphatase; Phosphomannomutase 1; PMM 1; PMMH-22; Secp53 homolog
Gene Aliases: C77612; PMM1; PMMH22; Sec53