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PMP22 Polyclonal Antibody
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Product Details
BS-0235R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PMP-22, amino acids 101-160.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charcot-Marie-Tooth neuropathy 1A (greatly reduced nerve conduction velocity, hereditary motor sensory neuropathy Ia); GAS-3; Growth arrest-specific protein 3; peripheral myelin; Peripheral myelin protein 22; peripheral myelin protein 22 kDa; PMP-22; PMP22; Protein CD25; SAG; Schwann cell membrane glycoprotein; SR13 myelin protein; unnamed protein product
Gene Aliases: 22kDa; Cd25; CIDP; CMT1A; CMT1E; DSS; GAS-3; GAS3; HMSNIA; HNPP; Pmp-22; PMP22; Sp110; Tr; trembler
UniProt ID: (Human) Q01453, (Rat) P25094, (Mouse) P16646
Entrez Gene ID: (Human) 5376, (Rat) 24660, (Mouse) 18858
apoptotic process
chemical synaptic transmission
nervous system development
peripheral nervous system development
negative regulation of cell proliferation
negative regulation of neuron projection development
cell differentiation
bleb assembly
myelin assembly
myelination
cell cycle arrest
cell death
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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