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Invitrogen
PMP70 Polyclonal Antibody, Biotin
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FIGURE: 1 / 9
PMP70 Antibody (PA1-1650) in WB
Western blot analysis of Peroxisomal Membrane Protein 70 (PMP70) was performed by loading the following whole cell extracts: 20 µg Rat Kidney (Lane 1), 20 µg Rat Liver (Lane 2), 20 µg Mouse Lung (Lane 3), 10 µg A431 cells (Lane 4), and 10 µg U2OS cells (Lane 5) per well onto a 4-20% Bis-Tris polyacrylamide gel. Proteins were transferred to a nitrocellulose membrane and the membrane was probed with Pierce Fast Western Kit (Product # 35050). The membrane was probed with PMP70 Polyclonal antibody (Product # PA1-650) at a dilution of 1:500 for... View More
Product Details
PA1-1650
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues C N(644) Y E F K K I T E D T V E F G S(659) of rat PMP70.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
Product Specific Information
PA1.1-650 detects peroxisomal membrane protein 70 from mouse, rat and human tissues.
PA1.1-650 has been successfully used in Western blot, ICC/IF and FACS procedures. By Western blot, this antibody detects an ~70 kDa protein representing PMP70 from mouse kidney protein extracts.
The PA1.1-650 immunogen is a synthetic peptide corresponding to residues C N(644) Y E F K K I T E D T V E F G S(659) of rat PMP70. This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single amino acid substitution. PA1.1-650 immunizing peptide (Cat. # PEP-038) is available for use in neutralization and control experiments.
Target Information
Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum" disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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