This antibody is predicted to react with mouse and rat based on sequence homology.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies . This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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Protein Aliases: 70 kDa peroxisomal membrane protein; ABC43; ABCD3; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; ATP-binding cassette, sub-family D, member 3; dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); peroxisomal membrane protein 1 (70kD, Zellweger syndrome); Peroxisomal membrane protein-1 (70kD); PMP70; PXMP1
Gene Aliases: ABC43; ABCD3; CBAS5; PMP70; PXMP1; ZWS2
UniProt ID: (Human) P28288
Entrez Gene ID: (Human) 5825
Molecular Function: transporter