|Western Blot (WB)||0.03-0.1 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Peptide with sequence C-SGQNPLRGPNDE, from the internal region of PNP (aa142-153)|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
This antibody is predicted to react with mouse and rat based on sequence homology.
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymis secretory sperm binding protein Li 156an; HEL-S-156an; Inosine phosphorylase; Inosine-guanosine phosphorylase; PNP; PRO1837; PUNP; Purine nucleoside phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase
Gene Aliases: NP; PNP; PRO1837; PUNP
UniProt ID: (Human) P00491
Entrez Gene ID: (Human) 4860
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