This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC138240; PC; PCLP antibody; PCLP1 antibody; PODLX2; Podocalyxin; Podocalyxin-like protein 1; podolyxin
Gene Aliases: PC; PCLP-1; Pclp1; podocalyxin; Podxl
UniProt ID: (Rat) Q9WTQ2
Entrez Gene ID: (Rat) 192181
Molecular Function: cell adhesion molecule