Immunogen sequence: SWDPAGYLLY CPCMGRFGNQ ADHFLGSLAF AKLLNRTLAV PPWIEYQHHK PPFTNLHVSY QKYFKLEPLQ AYHRVISLED FMEKLAPTHW PPEKRVAYCF EVAAQRSPDK KTCPMKEGNP FGPFWDQFHV SFNKSELFTG ISFSASYREQ WSQRRENHSC VTLLFPR; Positive Samples: HepG2, HL-60, Mouse heart, Mouse liver; Cellular Location: Endoplasmic reticulum
POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GDP-fucose protein O-fucosyltransferase 1; o-fucosyltransferase protein; O-FucT-1; Peptide-O-fucosyltransferase 1
Gene Aliases: DDD2; FUT12; KIAA0180; mKIAA0180; O-Fuc-T; O-FucT-1; O-FUT; OFUCT1; POFUT1