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Invitrogen
POLD1 Polyclonal Antibody
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Product Details
PA5-102728
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human POLD1(Accession P28340), corresponding to amino acid residues C1058-W1107.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total POLD1.
Target Information
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3'-5' exodeoxyribonuclease; CDC2 homolog; DNA polymerase delta 1, catalytic domain; DNA polymerase delta catalytic subunit; DNA polymerase delta, catalytic subunit; DNA polymerase subunit delta p125; DNA-directed DNA polymerase delta 1; POL D; POLD1; polymerase (DNA directed), delta 1, catalytic subunit 125kDa; polymerase (DNA) delta 1, catalytic subunit; Polymerase D
Gene Aliases: 125kDa; CDC2; CRCS10; IMD120; MDPL; POLD; POLD1
UniProt ID: (Human) P28340, (Rat) O54747, (Mouse) P52431
Entrez Gene ID: (Human) 5424, (Rat) 59294, (Mouse) 18971
nucleotide binding
nucleic acid binding
DNA binding
chromatin binding
damaged DNA binding
DNA-directed DNA polymerase activity
nuclease activity
exonuclease activity
protein binding
zinc ion binding
3'-5'-exodeoxyribonuclease activity
3'-5' exonuclease activity
transferase activity
nucleotidyltransferase activity
hydrolase activity
enzyme binding
DNA polymerase activity
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
DNA metabolism protein
DNA synthesis involved in DNA repair
DNA replication
DNA-dependent DNA replication
DNA repair
base-excision repair, gap-filling
nucleotide-excision repair, DNA gap filling
cellular response to DNA damage stimulus
response to UV
cellular response to UV
DNA replication proofreading
fatty acid homeostasis
error-free translesion synthesis
DNA biosynthetic process
DNA catabolic process, exonucleolytic
nucleic acid phosphodiester bond hydrolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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