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This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein Aliases: DNA polymerase delta smallest subunit p12; DNA polymerase delta subunit 4; DNA polymerase delta subunit p12; polymerase (DNA) delta 4, accessory subunit; polymerase (DNA-directed), delta 4, accessory subunit
Gene Aliases: p12; POLD4; POLDS
UniProt ID: (Human) Q9HCU8
Entrez Gene ID: (Human) 57804