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Product Details
15923-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
POLR1C Fusion Protein Ag8746 (1-346 aa encoded by BC008863) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.13 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MAASQAVEE MRSRVVLGEF GVRNVHTTDF PGNYSGYDDA WDQDRFEKNF RVDVVHMDEN SLEFDMVGID AAIANAFRRI LLAEVPTMAV EKVLVYNNTS IVQDEILAHR LGLIPIHADP RLFEYRNQGD EEGTEIDTLQ FRLQVRCTRN PHAAKDSSDP NELYVNHKVY TRHMTWIPLG NQADLFPEGT IRPVHDDILI AQLRPGQEID LLMHCVKGIG KDHAKFSPVA TASYRLLPDI TLLEPVEGEA AEELSRCFSP GVIEVQEVQG KKVARVANPR LDTFSREIFR NEKLKKVVRL ARVRDHYIFS VESTGVLPPD VLVSEAIKVL MGKCRRFLDE LDAVQMD (1-346 aa encoded by BC008863)
Target Information
RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis. RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA. Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, which suggests that multiple signaling pathways are involved in carrying out Pol I transcription. RPA16, RPA40 and RPA135 are subunits of Pol I that associate with each other at an early stage of RNA Pol I assembly. RPA40 is essential for the function and integrity of the complex and is also an essential subunit of RNA polymerase III (Pol III).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; polymerase (RNA) I polypeptide C; polymerase (RNA) I polypeptide C, 30kDa; polymerase (RNA) I subunit C; RNA polymerases I and III subunit AC1; RPA39; RPA40; RPC40
Gene Aliases: AC40; HLD11; POLR1C; POLR1E; RPA39; RPA40; RPA5; RPAC1; RPC40; TCS3
UniProt ID: (Human) O15160
Entrez Gene ID: (Human) 9533
Molecular Function:
DNA-directed RNA polymerase
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase III promoter
positive regulation of type I interferon production
positive regulation of gene expression, epigenetic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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