Immunogen sequence: LLQFPLGQDP SFLAIPILAL PPSDSLVPPY IVWYIVWPSA LISFLGCTLT VQFSNGKLQS PGNMRFTLYE NKDSTNPRKR NQRILAAETD RLSYVGNNFG
Highest antigen sequence identity to the following orthologs: Mouse - 44%, Rat - 40%.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:24207024). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024). [UniProt]
Protein Aliases: DNA-directed RNA polymerase I subunit E; DNA-directed RNA polymerase I subunit RPA49; FLJ13390; FLJ13970; polymerase (RNA) I associated factor 1; polymerase (RNA) I polypeptide E; polymerase (RNA) I polypeptide E, 53kDa; polymerase (RNA) I subunit E; RNA polymerase I subunit A49; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53; RP11-405L18.3
Gene Aliases: PAF53; POLR1E; PRAF1
UniProt ID: (Human) Q9GZS1
Entrez Gene ID: (Human) 64425