This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: PSDDNPVRAN LRTKGKQYCG KGEDLCANDS YVTIQNSELM SGSMDKGTLG SGSKNNIFYI LLRDWGQNEA ADAMSRLARL APVYLSNRGF SI
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3A is the largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase III subunit A; DNA-directed RNA polymerase III subunit RPC1; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; polymerase (RNA) III subunit A; RNA polymerase III 155 kDa subunit; RNA polymerase III subunit C1; RNA polymerase III subunit C160; RNA polymerase III subunit RPC155-D; RPC155
Gene Aliases: ADDH; HLD7; hRPC155; POLR3A; RPC1; RPC155
UniProt ID: (Human) O14802
Entrez Gene ID: (Human) 11128
Molecular Function: DNA-directed RNA polymerase